Compatibility studies of trioxsalen with excipients by DSC,DTA, and FTIR |
| |
| Authors: | Naiana G P B Lima Igor P B Lima Denise M C Barros Thays S Oliveira Fernanda N Raffin Túlio F A de Lima e Moura Ana C D Medeiros Ana P B Gomes Cícero F S Aragão |
| |
| Institution: | 1. Programa de Pós-gradua??o em Desenvolvimento e Inova??o Tecnológica em Medicamentos, Universidade Federal do Rio Grande do Norte, Caixa Postal 1524, Campus Universitário, Lagoa Nova, Natal, RN, 59078-970, Brazil
2. Laboratório de Desenvolvimento e Ensaios de Medicamentos, Universidade Estadual da Paraíba, Centro de Ciências Biológicas e da Saúde, Campina Grande, PB, 58.429-500, Brazil
|
| |
| Abstract: | Psoralens are widely used for the treatment of psoriasis. Trioxsalen is a drug prescribed low-dose, belonging to the group of substituted psoralen. The aim of this study was to evaluate the compatibility of trioxsalen with pharmaceutical excipients used in the solid forms by analytical techniques. Binary mixtures between the trioxsalen and pharmaceutical excipients (namely, magnesium stearate, α-lactose, microcrystalline cellulose 102, pregelatinized starch, mannitol, sodium lauryl sulfate, sodium starch glycolate, and croscarmellose sodium) were examined. The trioxsalen–sodium lauryl sulfate mixture displayed some physical interaction based on the DTA and DSC results, but the FTIR study ruled out any chemical change. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
