Studies on thermal,spectral, magnetic and biological properties of new Ni(II), Cu(II) and Zn(II) complexes with a bismacrocyclic ligand bearing an aromatic linker |
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Authors: | Cristina Bucur Mihaela Badea Mariana Carmen Chifiriuc Coralia Bleotu Emilia Elena Iorgulescu Irinel Adriana Badea Maria Nicoleta Grecu Veronica Lazăr Oana-Irina Patriciu Dana Marinescu Rodica Olar |
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Affiliation: | 1. Department of Inorganic Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania 2. Department of Microbiology, Faculty of Biology, University of Bucharest, 1-3 Aleea Portocalelor Str., 60101, Bucharest, Romania 3. Stefan S Nicolau Institute of Virology, 285?Mihai Bravu Ave., Bucharest, Romania 4. Department of Analytical Chemistry, Faculty of Chemistry, University of Bucharest, 90-92 Panduri Str., 050663, Bucharest, Romania 5. National Institute of Materials Physics, POB MG-7, 077125, M?gurele-Ilfov, Romania 6. Chemical and Food Engineering Department, Faculty of Engineering, “Vasile Alecsandri” University of Bacau, 157 Calea Marasesti, 600115, Bacau, Romania
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Abstract: | Novel complexes of M2LCl4·nH2O type (M:Ni, n = 4; M:Cu, n = 3 and M:Zn, n = 0; L: ligand resulted from 1,4-phenylenediamine, 3,6-diazaoctane-1,8-diamine and formaldehyde one-pot condensation) were synthesized and characterised by microanalytical, ESI–MS, IR, UV–Vis, 1H NMR and EPR spectra, magnetic data at room temperature and molar conductivities as well. The electrochemical behaviour of complexes was investigated by cyclic voltammetry. Simultaneous TG/DTA measurements were performed in order to evidence the thermal behaviour of the obtained complexes. Processes such as water elimination, fragmentation and oxidative degradation of the organic ligand as well as chloride elimination occurred during thermal decomposition. The antimicrobial assays demonstrate that the compounds exhibited good antibacterial activity, especially against S. aureus and E. coli strains, the most active being the copper(II) complex, which also exhibited the most prominent anti-biofilm effect, suggesting its potential use for the development of new antimicrobial agents. The biological activity was correlated with log P ow values. All complexes disrupt the membrane integrity of HCT 8 tumour cells. |
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