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Thermal properties of betulin dipropionate and its mixtures with polymers |
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| Authors: | V A Drebushchak M A Mikhailenko Tatyana P Shakhtshneider Tatiana N Drebushchak Svetlana A Kuznetsova Ju N Malyar |
| Institution: | 1. Institute of Geology and Mineralogy, SB RAS, Pr. Ac. Koptyuga 3, Novosibirsk, 630090, Russia 2. Novosibirsk State University, Ul. Pirogova 2, Novosibirsk, 630090, Russia 3. Institute of Solid State Chemistry and Mechanochemistry, SB RAS, Ul. Kutateladze 18, Novosibirsk, 630128, Russia 4. Institute of Chemistry and Chemical Technology, SB RAS, K. Marx Street 42, Akademgorodok 50/24, Krasnoyarsk, 660049, Russia 5. Siberian Federal University, 79 Svobodny, Krasnoyarsk, 660041, Russia |
| Abstract: | Melting of betulin dipropionate (3β,28-di-O-propionyl-lup-20(29)-lupene) of high purity (orthorhombic P212121, a = 1.27409(2), b = 1.57316(3), c = 1.59810(3) nm) and its mixtures with four excipients was investigated with DSC and TG. Melting point is 163.6 °C (?f H = 33 kJ mol?1). Smaller values reported recently were measured for not pure samples. The melt of betulin dipropionate remains glassy under ambient conditions and does not crystallize during the second heating. In mixture with excipients (arabinogalactan, polyethylene glycol, polyvinylpyrrolidone, and fumed silica), the betulin dipropionate loses its crystal structure after mechanical activation. |
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