| MODERN NMR TECHNIQUES FOR THE STUDY OF LARGE PROTEINS IN SOLUTION |
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| 作者单位： | Daiwen YANG(Departments of Biological Sciences and Chemistry,National University of Singapore,Singapore 117543);Lewis E.KAY(Department of Medical Genetics,University of Toronto,Canada M5S 1A8) |
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| 摘 要： | A number of important methodological developments in high resolution NMR spectroscopy have led to significant increases in the size limitations that previously impeded solution structural studies of macromolecules. Specifically, isotope labeling and TROSY triple resonance spectroscopy has resulted in substantial sensitivity and resolution gain for applications to large molecular weight proteins.
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| 关 键 词： | NMR spectroscopy molecular weight high resolution |
MODERN NMR TECHNIQUES FOR THE STUDY OF LARGE PROTEINS IN SOLUTION |
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| Daiwen YANG,Lewis E.KAY. MODERN NMR TECHNIQUES FOR THE STUDY OF LARGE PROTEINS IN SOLUTION[J]. Chinese Journal of Magnetic Resonance, 2002, 19(1): 78-78 |
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| Authors: | Daiwen YANG Lewis E.KAY |
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| Affiliation: | 1. Departments of Biological Sciences and Chemistry,National University of Singapore,Singapore 117543;2. Department of Medical Genetics,University of Toronto,Canada M5S 1A8 |
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| Abstract: | A number of important methodological developments in high resolution NMR spectroscopy have led to significant increases in the size limitations that previously impeded solution structural studies of macromolecules. Specifically, isotope labeling and TROSY triple resonance spectroscopy has resulted in substantial sensitivity and resolution gain for applications to large molecular weight proteins. |
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