| NMR AND DFT STUDY OF Co-C BOND ACTIVATION MECHANISM IN VITAMIN B_(12) COMPOUNDS |
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| 作者单位： | Department of Chemistry,The Chinese University of Hong Kong Shatin,New Territories,Hong Kong SAR
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| 摘 要： | This report focuses on a theoretical study of the cobalt-cabon bond activation mechanism in Vitamin B12, its co enzyme complexes, and model compounds such as cobalamins (Cbl), cobaloximes and cobalt porphyrins. In particular, emphasis is placed on the nucleotide loop and its role in the base on and base off mechanism.
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| 关 键 词： | theoretical study |
NMR and DFT Study of Co-C Bond Activation Mechanism in Vitamin B12 Compounds |
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| Authors: | William WLYIM Steve CFAU YEUNG |
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| Institution: | Department of Chemistry,The Chinese University of Hong Kong Shatin,New Territories,Hong Kong SAR |
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| Abstract: | This report focuses on a theoretical study of the cobalt-cabon bond activation mechanism in Vitamin B12, its coenzyme complexes, and model compounds such as cobalamins (Cbl), cobaloximes and cobalt porphyrins. In particular, emphasis is placed on the nucleotide loop and its role in the baseon and baseoff mechanism. |
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