Synthesis, characterization, and thermal decomposition of new copper (II) complex compounds with chlorhexidine |
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Authors: | Mihaela Badea Rodica Olar Monica Iliş Rodica Georgescu Mirela Călinescu |
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Institution: | 1. Faculty of Chemistry, University of Bucharest, Dumbrava Ro?ie 23, 020462, Bucharest, Romania 2. Research Development National Institute for Physics and Nuclear Engineering Horia Hulubei, Atomi?tilor, 1, 077125, Bucharest, M?gurele, Romania
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Abstract: | Three new copper (II) complex compounds with chlorhexidine (CHX) as ligand have been prepared and characterized by elemental and thermogravimetrical analyses, molar conductances, infrared, and UV–Vis spectra. Chlorhexidine acts as neutral tetradentate NNNN donor, coordinating through the four imine nitrogen atoms. Based on the experimental data the following formulas have been proposed for the complex compounds: Cu(CHX)](NO3)2 (1), Cu2(CHX)Br2Cl2]·4H2O (2), and Cu(CHX)Cl]Cl (3). Thermal decomposition evidenced dehydration (complex 2), anionic moieties release and the ligand cleavage with chlorobenzene moieties removal for all complexes. The final residue is in all cases copper oxide. Antibacterial and antifungal activities of the complexes have been determined in vitro, by the cup-plate agar diffusion method, against Escherichia coli, Staphyloccocus aureus, and Candida albicans. The complexes present an activity comparable to that of chlorhexidine, the most active being Cu2(CHX)Br2Cl2]·4H2O. |
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