Thermal stability of ketoprofen |
| |
Authors: | Dumitru Tiţa Adriana Fuliaş Bogdan Tiţa |
| |
Affiliation: | 1. “Victor Babe?”, Faculty of Pharmacy, University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041, Timisoara, Romania
|
| |
Abstract: | The purpose of this investigation is to calculate the kinetic parameters and the kinetic model for the studied process. The results are further used to predict the system’s behaviour in various circumstances. A kinetic study regarding the ketoprofen—involving active substance’s thermal decomposition—was performed under isothermal conditions and in a nitrogen atmosphere, for the temperature steps: 260; 265; 270; 275; and 280 °C. The thermogravimetry/derivative thermogravimetry data were processed by three differential methods: isothermal–isoconversional, Friedman’s isothermal–isoconversional, and isothermal model-fittings. The obtained results are in good accordance with those obtained under non-isothermal conditions of a previous study, and confirm the necessity for the kinetic parameters to be determined, under different thermal conditions, by the adequate calculation methods. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|