Total synthesis of the duocarmycins |
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| Authors: | Yamada Ken Kurokawa Toshiki Tokuyama Hidetoshi Fukuyama Tohru |
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| Institution: | Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan. |
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| Abstract: | The total synthesis of (+)-duocarmycin A and SA through a common indoline intermediate is described. The key reactions include selective lithiation of a 2,6-dibromoiodobenzene derivative and diastereoselective addition to a chiral nitroalkene, copper-mediated aryl amination, and addition of aryllithium to azlactones. |
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