|
|||||
|
|
A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging |
|
| Authors: | Teruaki Toyota Tadashi Hanafusa Takashi Oda Iwane Koumura Takanori Sasaki Eiji Matsuura Hiromi Kumon Tsuneo Yano Toshiro Ono |
| Institution: | 1. Department of Radiation Research, Advanced Science Research Center, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan 2. Graduate School of Health Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan 3. Quantum Equipment Division, Sumitomo Heavy Industries, Ltd., 2-1-1 Osaki, Shinagawa-ku, Tokyo, 141-6025, Japan 4. Collaborative Research Center for Okayama Medical Innovation Center, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan |
| Abstract: | Ion exchange is a simple and efficient method for separating no-carrier-added 64Cu from an irradiated Ni target. We developed a semi-automated two-round 64Cu separation system equipped with a strong-base anion exchange resin column. We first verified the efficiency of the system using a non-radioactive substitute consisting of 25 mg of Ni and 127 ng of Cu, and confirmed that Cu was completely eluted at the second round of the separation step. After the bombardment, separation of 64Cu from the Ni target was achieved with high radiochemical purity. 64Cu produced and separated in this study had an extremely low level of Ni impurity. It could be used for labeling monoclonal antibodies for antibody positron emission tomography imaging and synthesizing radiopharmaceuticals. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |