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Changes in the 5-HT2A receptor system in the pre-mammillary hypothalamus of the ewe are related to regulation of LH pulsatile secretion by an endogenous circannual rhythm |
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| Authors: | Philippe Chemineau Agnès Daveau Jean Pelletier Beno?t Malpaux Fred J Karsch and Catherine Viguié |
| Institution: | (1) Equipe de Neuroendocrinologie et Ma?trise des Fonctions Saisonni?res, Unit? de Physiologie de la Reproduction et des Comportements, UMR INRA-CNRS- Univ. F. Rabelais, 37380 Nouzilly, France;(2) Reproductive Sciences Program and Department of Physiology, University of Michigan, Ann Arbor, Michigan 48109-0404, USA;(3) Present adress: UMR 181, INRA-ENVT 23 chemin des Capelles, 31076 Toulouse, France |
| Abstract: | BackgroundWe wanted to determine if changes in the expression of serotonin 2A receptor (5HT2A receptor) gene in the premammillary hypothalamus are associated with changes in reproductive neuroendocrine status. Thus, we compared 2 groups of ovariectomized-estradiol-treated ewes that expressed high vs low LH pulsatility in two different paradigms (2 groups per paradigm): (a) refractoriness (low LH secretion) or not (high LH secretion) to short days in pineal-intact Ile-de-France ewes (RSD) and (b) endogenous circannual rhythm (ECR) in free-running pinealectomized Suffolk ewes in the active or inactive stage of their reproductive rhythm. |
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