| Ge-132稀土配合物及其对单核苷酸磷酯键的催化水解作用 |
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| 引用本文： | 王志强,陈继,朱兵,张树功.Ge-132稀土配合物及其对单核苷酸磷酯键的催化水解作用[J].高等学校化学学报,1998,19(12):1915-1917. |
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| 作者姓名： | 王志强 陈继 朱兵 张树功 |
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| 作者单位： | 中国科学院长春应用化学研究所稀土化学与物理开放实验室, 长春, 130022 |
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| 摘 要： | Ｇｅ－１３２是具有广泛生物活性的一元羧酸有机锗倍半氧化物的低聚物，分子中存在类似冠醚的Ｇｅ－Ｏ－Ｇｅ大环结构．因此，有人认为Ｇｅ－１３２的生物活性可能与这种大环结构与体内金属离子形成配合物有关［１］，但尚无直接的实验证据．因此，合成Ｇｅ－１３２稀土配...
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| 关 键 词： | Ge-132稀土配合物 5'-AMP 5'-dAMP 催化水解 |
| 收稿时间： | 1997-10-15 |
| 修稿时间： | 1997年10月15日 |
Rare Earth Complexes with Ge-132 and Their Catalytic Hydrolysis to Phosphatide Bond of Mononucleotide |
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| WANG Zhi-Qiang,CHEN ji,ZHU Bing,ZHANG Shu-Gong.Rare Earth Complexes with Ge-132 and Their Catalytic Hydrolysis to Phosphatide Bond of Mononucleotide[J].Chemical Research In Chinese Universities,1998,19(12):1915-1917. |
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| Authors: | WANG Zhi-Qiang CHEN ji ZHU Bing ZHANG Shu-Gong |
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| Institution: | Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 |
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| Abstract: | The complexes of a series of rare earths with Ge-132 have been prepared. The carboxyl anions of Ge-132 molecule were coordinated to rare earth ion with chelate style. In the complexes molecule, the GeO3/2 group of Ge-132 were hydrolyzed to become Ge(OH)3 group, and later does not coordinate with rare earth ions. All of the complexes possess similar properties. In aqueous solution of pH6 and 50 ℃, these complexes can obviously selectively catalytically hydrolize the phosphatide bond of 5'-AMPand 5'-dAMPinto phosphatic acid and riboside. |
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| Keywords: | Rare earth complex with Ge-132 5'-AMP 5'-dAMP Catalysis hydrolysis |
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