| 二价金属离子对磷脂聚集体的影响 |
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| 引用本文： | 俞科兵,杨展澜,张莉,王凡,翁诗甫,吴瑾光.二价金属离子对磷脂聚集体的影响[J].物理化学学报,2003,19(8):747-750. |
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| 作者姓名： | 俞科兵 杨展澜 张莉 王凡 翁诗甫 吴瑾光 |
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| 作者单位： | State Key Laboratory of Rare Earth Materials Chemistry and Applications, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 |
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| 基金项目： | 国家自然科学基金(20171004、20023005)，“箘政”基金资助项目~~ |
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| 摘 要： | 通过浊度分析和激光光散射光谱研究了二价金属离子（Ca2＋、Cu2＋和Mn2＋）对蛋黄卵磷脂(EYPC)聚集态的影响.结果表明，自由的二价金属离子对EYPC囊泡有破坏作用,并使EYPC囊泡发生相转变,形成胶束;而与牛磺胆酸钠(TC)结合的二价金属离子使EYPC囊泡半径减小,但不破坏EYPC囊泡.
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| 关 键 词： | 卵磷脂（PC） 二价金属离子 牛磺胆酸钠(TC) 聚集态 |
| 收稿时间： | 2003-01-23 |
| 修稿时间： | 2003年1月23日 |
Influence of Divalent Metal Ions on the Aggregation Properties of EYPC |
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| Yu Ke-Bing Yang Zhan-Lan Zhang Li Wang Fan Weng Shi-Fu Wu Jin-Guang.Influence of Divalent Metal Ions on the Aggregation Properties of EYPC[J].Acta Physico-Chimica Sinica,2003,19(8):747-750. |
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| Authors: | Yu Ke-Bing Yang Zhan-Lan Zhang Li Wang Fan Weng Shi-Fu Wu Jin-Guang |
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| Institution: | State Key Laboratory of Rare Earth Materials Chemistry and Applications, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 |
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| Abstract: | It is well known that phosphatidylcholine (PC) vesicles are predomina nt carriers of cholesterol in human bile.Although the interaction of bile salts with PC has been extensively studied,relatively little attention has been given to effects of divalent metal ions on the aggregation properties of PC.We used bo th light scattering and UV spectroscopies to follow the effects of divalent meta l ions on EYPC (egg yellow PC) vesicles.We conclude that when divalent metal ion s existed,the mixed vesicles formed by PC and TC (sodium taurocholate) with the ratio of 1:3 were more stable.Free divalent metal ions act to precipitate unilam ellar PC vesicles whereas,in combination with sodium taurocholate,these ions act to decrease the size of PC vesicles and induce a phase transition from PC vesic les to mixed micelles.It is a possible reason for gallstones formation when extr a free divalent metal ions exist in human bile. |
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| Keywords: | Phosphatidylcholine Divalent metal ions Sodium taurocholate Aggre gation properties |
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