| a,a,a,b-ZnT(o-BocThr)APP对咪唑衍生物和氨基酸酯的分子识别研究 |
| |
| 引用本文： | 阮文娟,赵小箐,王树军,章应辉,张智慧,南晶,朱志昂,王建国,马毅.a,a,a,b-ZnT(o-BocThr)APP对咪唑衍生物和氨基酸酯的分子识别研究[J].中国化学,2005,23(10):1381-1386. |
| |
| 作者姓名： | 阮文娟 赵小箐 王树军 章应辉 张智慧 南晶 朱志昂 王建国 马毅 |
| |
| 作者单位： | [1]Department of Chemistry, Nankai University, Tianjin 300071, China [2]National Pesticide Engineering Research Center, Nankai University, Tianjin 300071, China |
| |
| 基金项目： | Project supported by the National Natural Science Foundation of China （Nos. 20271030 and 20303009） and the Tianjin Natural Science Foundation （No. 023604011）. |
| |
| 摘 要： | Molecular Recognition of α,α,α,β-ZnT（o-BocThr）APP （1） toward a series of imidazole derivatives and amino acid esters was investigated. Association constants were determined in chloroform by means of UV-Vis titration method. The association constants of 1 with imidazole derivatives are larger than those of 1 with amino acid esters. 1H NMR spectra were investigated to describe the binding mode of the recognition system, showing that all the protons of the guests were shifted to upfield. The circular dichroism spectra of 1-L-/D-ValOMe showed a split cotton effect in Soret region, while those of 1-L-/D-PheOMe showed no split cotton effect. Molecular modeling was performed to understand chiral recognition on a molecular level. Quantum chemical calculation was carried out based on the stable conformations of these recognition systems, which gave a reasonable explanation for the behavior of molecular recognition. The results indicated that the conformation of 1-D-ValOMe was more stable than that of 1-L-ValOMe.
|
| 关 键 词： | 氨基酸 手性化合物 分子结构 光谱分析 咪唑 |
| 收稿时间： | 2005-01-05 |
| 修稿时间： | 2005-01-052005-06-14 |
Study on the Molecular Recognition of α,α,α,β‐ZnT(o‐BocThr)APP toward Imidazole Derivatives and Amino Acid Esters |
| |
| Ruan WenJuan;Zhao XiaoQing;Wang ShuJun;Zhang YingHui;Zhang ZhiHui;Na Jing;Zhu ZhiAng;Wang JianGuo;Ma Yi.Study on the Molecular Recognition of α,α,α,β‐ZnT(o‐BocThr)APP toward Imidazole Derivatives and Amino Acid Esters[J].Chinese Journal of Chemistry,2005,23(10):1381-1386. |
| |
| Authors: | Ruan WenJuan;Zhao XiaoQing;Wang ShuJun;Zhang YingHui;Zhang ZhiHui;Na Jing;Zhu ZhiAng;Wang JianGuo;Ma Yi |
| |
| Abstract: | Molecular Recognition of α,α,α,β‐ZnT(o‐BocThr)APP ( 1) toward a series of imidazole derivatives and amino acid esters was investigated. Association constants were determined in chloroform by means of UV‐Vis titration method. The association constants of 1 with imidazole derivatives are larger than those of 1 with amino acid esters. 1H NMR spectra were investigated to describe the binding mode of the recognition system, showing that all the protons of the guests were shifted to upfield. The circular dichroism spectra of 1 ‐L‐/D‐ValOMe showed a split cotton effect in Soret region, while those of 1 ‐L‐/D‐PheOMe showed no split cotton effect. Molecular modeling was performed to understand chiral recognition on a molecular level. Quantum chemical calculation was carried out based on the stable conformations of these recognition systems, which gave a reasonable explanation for the behavior of molecular recognition. The results indicated that the conformation of 1 ‐D‐ValOMe was more stable than that of 1 ‐L‐ValOMe. |
| |
| Keywords: | chiral porphyrin molecular recognition circular dichroism spectra configuration analysis quantum chemistry calculation |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《中国化学》浏览原始摘要信息 |
| 点击此处可从《中国化学》下载免费的PDF全文 |
|
