In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective |
| |
| Authors: | Henry Pierre-Gilles Adriany Gregor Deelchand Dinesh Gruetter Rolf Marjanska Malgorzata Oz Gülin Seaquist Elizabeth R Shestov Alexander Uğurbil Kâmil |
| |
| Institution: | Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA. henry@cmrr.umn.edu |
| |
| Abstract: | In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
