Synthesis of 10-Hydroxycamptothecin: Evaluation of New Moderators for the Chemoselective Reduction of Camptothecin |
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| Authors: | N M Sekhar Yerramilli Anjaneyulu |
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| Institution: | 1. Research and Development, Integrated Product Development, Dr. Reddy's Laboratories Ltd. , Ranga Reddy District , Andhra Pradesh , India;2. Ecologic Technologies Pvt. Ltd. , Hyderabad , Andhra Pradesh , India |
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| Abstract: | Abstract 10-Hydroxycamptothecin is prepared by chemoselective catalytic hydrogenation of the B-ring of camptothecin over PtO2 with sulfur moderators followed by oxidation using iodobenzenediacetate. New moderators (viz. thioanisole, dimethyl sulfide, diphenyl sulfide, 2-mercapto ethanol), which moderate the hydrogenation of the B- ring of camptothecin, are being explored.  ACKNOWLEDGMENTS The authors thank the management of Dr. Reddy's Laboratories Ltd. for supporting this work, and support from analytical colleagues is highly appreciated. |
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| Keywords: | Camptothecin DMSO 10-hydroxycamptothecin moderator thioanisole |
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