|
|||||
|
|
N-Acyliminium Cyclization as an Approach for an Asymmetric Synthesis of the Pyrrolo[2,1-a]benzazepine Ring System |
|
| Authors: | Steven M. Allin Joannah M. R. Towler Mark R. J. Elsegood Basu Saha Philip C. Bulman Page |
| Affiliation: | 1. School of Physical and Geographical Sciences , Keele University , Keele , United Kingdom s.m.allin@chem.keele.ac.uk;3. Department of Chemistry , Loughborough University , Loughborough , United Kingdom;4. Department of Chemical Engineering , Loughborough University , Loughborough , United Kingdom;5. School of Chemistry , University of East Anglia , Norwich , United Kingdom |
| Abstract: | Abstract In this article, we report a facile asymmetric synthesis of the pyrrolo[2,1-a]benzazepine ring system based around a stereoselective N-acyliminium cyclization of a novel chiral lactam template. |
| Keywords: | Alkaloid aminoalcohol asymmetric cyclization N-acyliminium |