Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin |
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| Authors: | Hsieh Yves S Y Taleski Deni Wilkinson Brendan L Wijeyewickrema Lakshmi C Adams Ty E Pike Robert N Payne Richard J |
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| Affiliation: | School of Chemistry, The University of Sydney, NSW 2006, Australia. |
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| Abstract: | Synthesis of sulfated and unsulfated (glyco)peptide fragments of Hirudin P6 (a potent anticoagulant from the leech Hirudinaria manillensis) is described. The effect of O-glycosylation and tyrosine sulfation on thrombin binding and peptidolytic activity was investigated, together with the inhibition of fibrinogen cleavage. |
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