Development and applications of a microfluidic reactor with multiple analytical probes |
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Authors: | Greener Jesse Tumarkin Ethan Debono Michael Kwan Chi-Hang Abolhasani Milad Guenther Axel Kumacheva Eugenia |
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Affiliation: | Department of Chemistry, University of Toronto, 80 Saint George street, Toronto, Ontario M5S 3H6, Canada. |
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Abstract: | We report the development of a versatile microfluidic (MF) reactor with multiple analytical probes, which can be used for (i) quantitative characterisation of molecular vibrational signatures of reactants or products, (ii) the localised real-time monitoring of temperature and (iii) site-specific measurements of pH of the reaction system. The analytical probes utilised for in situ reaction analysis include an ATR-FTIR probe, a temperature probe, and a pH probe. We demonstrate the applications of the MF reactor with integrated probes for the parallel monitoring of multiple variables in acid/base neutralisation reaction, of changes in buffer pH, temperature, and vibrational absorption bands, and for monitoring the kinetics of the reaction between CO(2) and a buffer system with therapeutic applications. |
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