Spectral and biological studies of copper(II) complexes of 2-acetyl-pyridine thiosemicarbazones with bulky 4N-substituents |
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| Authors: | Douglas X West Haileselassie Gebremedhin Timothy J Romack Anthony E Liberta |
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| Institution: | (1) Department of Chemistry, Illinois State University, 61761 Normal, Illinois, USA;(2) Department of Biological Sciences, Illinois State University, 61761 Normal, Illinois, USA |
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| Abstract: | Summary Copper(II) complexes of a large number of 2-acetylpyridine 4N-alkyl thiosemicarbazones were prepared and characterized. I.r., electronic and e.s.r. spectra of the complexes, as well as 1H and 13C n.m.r. spectra of the thiosemicarbazones, were obtained. Both the thiosemicarbazones and their complexes show either modest or no growth inhibitory activity against Aspergillus niger, but many have considerable activity against Paecilomyces variotii. There is a relationship between the antifungal activity and size of the 4N-substituent for both the thiosemicarbazones and their copper(II) complexes. |
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