苦参碱在多壁碳纳米管修饰玻碳电极上的电催化氧化及其电分析方法

研究了苦参碱(Matrine, MT) 在多壁碳纳米管修饰玻碳电极(MWCNT/GCE)上的电化学行为. 与GCE相比, MT在MWCNT/GCE上峰电位负移120 mV, 峰电流增大约2.5倍, 表明MWCNT/GCE对MT的电化学氧化具有良好的催化作用. 同时测定并计算了MT在MWCNT/GCE上的电极过程动力学参数: 电子转移系数α、电极反应速率常数ks、扩散系数D. 运用差分脉冲伏安法对苦参碱样品含量进行测定, 相对标准偏差为0.12%～2.9%, 加标回收率为98.4%～99.0%. 该方法可用于MT的电化学定量测定.

Electrocatalytic oxidation of matrine at a multi-wall carbon nanotubes modified glassy carbon electrode and its electrochemical determination

Electrochemical behaviors of matrine (MT) on a multi-wall carbon nanotubes modified glassy carbon electrode (MWCNT/GCE) were investigated. The experimental results showed that the oxidation peak potential shifted negatively by 120 mV, and the oxidation peak current increased 2.5 times at the MWCNT/GCE in comparison with that at the bare GCE, which indicated that the MWCNT/GCE could catalyze the electrochemical oxidation of MT very well. At the same time the electron transfer coefficient α, the electrode reaction rate constant ks and the diffusion coefficient D were calculated. Determination of the content of commercial MT pharmaceutical products was performed by differential pulse voltammetry (DPV). The relative standard deviations were 0.12%～2.9% and the recoveries were in the range of 98.4%～99.0%. This method can be applied to quantitative determination of MT with both low detection limit and high sensitivity.