| (E)-1-氯-6,6-二甲基-2-庚烯-4-炔的立体选择性合成 |
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| 引用本文： | 谢素雯,胡孝贵.(E)-1-氯-6,6-二甲基-2-庚烯-4-炔的立体选择性合成[J].化学通报,2007,70(3):237-239. |
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| 作者姓名： | 谢素雯 胡孝贵 |
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| 作者单位： | 江西应用技术职业学院应用化学系,赣州,341000;江西应用技术职业学院应用化学系,赣州,341000 |
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| 摘 要： | (E)-1-氯-6,6-二甲基-2-庚烯-4-炔是合成盐酸特比萘芬的关键中间体,N-氯代二异丙胺/三苯基膦与6,6-二甲基-1-庚烯-4-炔-3-醇反应,可以立体选择性地得到反式的该化合物,其反式/顺式异构体的比例达9/1,为特比萘芬提供了可工业放大生产的立体选择性合成方法。
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| 关 键 词： | 盐酸特比萘芬 (E)-1-溴(氯)-6 6-二甲基-2-庚烯-4-炔 N-氯代二异丙胺 |
| 修稿时间： | 2006-04-25 |
Stereoselective Synthesis of (E)-1-Chloro-6,6-dimethyl-2-hepten-4-yne |
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| Xie Suwen,Hu Xiaogui.Stereoselective Synthesis of (E)-1-Chloro-6,6-dimethyl-2-hepten-4-yne[J].Chemistry,2007,70(3):237-239. |
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| Authors: | Xie Suwen Hu Xiaogui |
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| Institution: | Department of Applied Chemistry, Jianxi College of Applied Technology, Ganzhou 341000 |
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| Abstract: | The stereoselective halogenation of 6,6-dimethyl-1-hepten-4-yn-3-ol using ClN(Pr~i)_2/PPh_3 is described in this paper.The resulting(E)-1-chloro-(6,6)-dimethyl-2-hepten-4-yne,a key intermediate for terbinafine,an antifungal agent,is obtained in good yield which stereoselectivity E/Z=9/1. |
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| Keywords: | Terbinafine (E)-1-Chloro-6 6-dimethyl-2-hepten-4-yne ClN(Pr~i)_2 |
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