Asymmetric synthesis of α-chiral dihydrocinnamates by catalytic reductive aldol coupling and subsequent dehydroxylation |
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| Authors: | Toru Hashimoto Takushi Shiomi Jun-ichi Ito Hisao Nishiyama |
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| Institution: | aDepartment of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan |
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| Abstract: | Optically active dihydrocinnamate derivatives bearing the chiral carbon center at α-position were synthesized by Rh(Phebox)-catalyzed asymmetric reductive aldol coupling reaction with substituted cinnamates and benzaldehyde derivatives and subsequent dehydroxylation reaction. |
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| Keywords: | Rhodium Reductive aldol Dihydrocinnamate Asymmetric catalysis |
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