新型水溶性手性Salen配合物的合成及性质研究

合成并表征了新型水溶性手性Salen 配体(R,R)-N,N’-二{4-[2-(三甲胺基)乙氧基]水杨醛}-1,2-环己二胺二高氯酸盐(L)及金属配合物ML [M＝Zn(II), Cu(II), Ni(II), Co(II), Fe(III), Mn(III)]. 讨论了手性配体L及配合物ZnL的电子光谱和圆二色光谱性质, 用UV-Vis光谱滴定和CD光谱滴定法研究了ZnL对手性氨基酸对映异构体的分子识别. 测定了主体ZnL与客体氨基酸轴向配位反应的配位数(n)、缔合常数(K)及热力学函数 测得缔合常数的大小顺序为KPhe＞KVal＞KThr. 研究发现反应是放热、熵减小的过程. 用凝胶电泳的方法初步研究了此类手性金属配合物在H2O2存在下对DNA的裂解作用.

Study on Synthesis and Properties of Novel Water Soluble Chiral Salen Complexes

Chiral salen ligand with quaternary ammonium groups,(R,R)-1,2-bis{4-[2-(trimethylammonium)-ethoxy]-2-hydroxy-salicylideneamino}cyclohexane perchlorate(L) and ML complexes [M=Zn(II),Cu(II),Ni(II),Co(II),Fe(III),Mn(III)] were synthesized and characterized.The electronic spectra and circular dichro-ism spectra were discussed.By UV-Vis and CD spectrophotometry,the molecular recognition of the host ZnL toward amino acid was studied.The coordination number(n),equilibrium constants(K) and thermodynamic parameters(...