Solvent-free synthesis of 6-unsubstituted dihydropyrimidinones using 2-pyrrolidonium bisulphate as efficient catalyst |
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| Authors: | Heshmatollah Alinezhad Mahmood Tajbakhsh Mahboobeh Zare Mahbooeh Mousavi |
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| Institution: | 1.Faculty of Chemistry,University of Mazandaran,Babolsar,Iran;2.Faculty of Science and Herbs,Amol University of Special Modern Technologies,Amol,Iran |
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| Abstract: | A one-pot three-component Biginelli-like reaction of enaminones, aldehydes with urea/thiourea in the presence of 2-pyrrolidonium bisulphate as an acidic ionic liquid catalyst for the preparation of 6-unsubstituted dihydropyrimidinones is described. The excellent yield, short reaction time, simple procedure and avoidance of the use of organic solvents are some advantages of this method. |
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