A two-step, one-pot enzymatic synthesis of 2-substituted 1,3-diols |
| |
Authors: | Kalaitzakis Dimitris Smonou Ioulia |
| |
Affiliation: | Department of Chemistry, University of Crete, Heraklion 71003, Crete, Greece. |
| |
Abstract: | A biocatalytic cascade reaction was designed for the stereoselective synthesis of optically pure 2-alkyl-1,3-diols employing two enzymes. The cascade process consists of two consecutive steps: a stereoselective diketone reduction and a hydroxy ketone reduction. Chiral diols were formed by the addition of ketoreductases in the same vessel, in high stereoselectivity and chemical yield, without the isolation of the intermediate β-hydroxy ketones. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|