Concise synthesis of the Erythrina alkaloid 3-demethoxyerythratidinone via combined rhodium catalysis |
| |
Authors: | Joo Jung Min David Ramoncito A Yuan Yu Lee Chulbom |
| |
Institution: | Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA. |
| |
Abstract: | The total synthesis of the erythrina alkaloid 3-demethoxyerythratidinone has been achieved via a strategy based on combined rhodium catalysis. The catalytic tandem cyclization effected by the interplay of alkynyl and vinylidene rhodium species allows for efficient access to the A and B rings of the tetracyclic erythrinane skeleton in a single step. The synthesis also features rapid preparation of the requisite precursor for the double ring closure and thus has been completed in only 7 total steps in 41% overall yield. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|