Separation of the enantiomers of some potassium channel activators using an alpha 1-acid glycoprotein column. |
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Authors: | J M Evans R J Smith G Stemp |
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Institution: | SmithKline Beecham Pharmaceuticals, Pinnacles, Harlow, Essex, UK. |
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Abstract: | The separations of the enantiomers of some 3,4-dihydro-2,2'-dimethyl-2H-1-benzopyrans and a related tetrahydronaphthalene on alpha 1-acid glycoprotein (Chiral-AGP) are presented, together with the results from an investigation of the effects of organic modifier and pH on the separations achieved. The general utility of Chiral-AGP in separating the enantiomers of compounds from this class of antihypertensive agents is demonstrated in this paper. |
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