| Selectively reductive cleavage of the protected taxol side chain with sodium borohydride |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | During the course of our studies on the taxol chemistry,we have ever tried thereductive cleavage of the acotyl group at 20-C in compound 1a~(1,2) with the hydroxylgroup assistance at 4-C by sodium borohydride. However, the major product 2a~2(27%)still had the acetyl group at 20-C and the signal for the 10-C proton at 6.61 ppm(s)was shifted to 6.31 ppm(d, J=3.79 Hz). A new doublet signal at 3.62 ppm(d, J=3.80
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Selectively reductive cleavage of the protected taxol side chain with sodium borohydride |
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| Yu Cheng-Zhi,Cheng Wei,Liu Zhi-Yu. Selectively reductive cleavage of the protected taxol side chain with sodium borohydride[J]. Chinese Journal of Chemistry, 1996, 14(4): 381-384. DOI: 10.1002/cjoc.19960140418 |
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| Authors: | Yu Cheng-Zhi Cheng Wei Liu Zhi-Yu |
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| Abstract: | |
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| Keywords: | Taxol cephalomannine baccatin III reductive cleavage side chain |
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