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Artificial nano‐pin as a temporal molecular glue for the targeting of acidic tumor cells |
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| Authors: | Nam Muk Oh Kyung Taek Oh Yu Seok Youn Eun Seong Lee |
| Affiliation: | 1. Department of Biotechnology, The Catholic University of Korea, , Bucheon, Gyeonggi‐do, 420‐743 Republic of Korea;2. College of Pharmacy, Chung‐Ang University, , Seoul, 155‐756 Republic of Korea;3. College of Pharmacy, Sungkyunkwan University, , Suwon‐si, Gyeonggi‐do, 440‐746 Republic of Korea |
| Abstract: | Highly precise control of molecular structure for developing efficient anticancer drug delivery is challenging. Our method reported herein can satisfy the need for building novel hybrid molecule; this molecule serves as a built‐in transformer that changes its molecular configuration from a pin‐shaped arrangement to a dog bone‐shaped arrangement. This approach led to a significant increase in the efficiency of tumor inhibition. Copyright © 2014 John Wiley & Sons, Ltd. |
| Keywords: | nano‐pin dog bone‐shaped pin‐shaped acidic tumor targeting photosensitizing drug |