Microwave-assisted preparation of fused bicyclic heteroaryl boronates: application in one-pot Suzuki couplings |
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| Authors: | DiMauro Erin F Vitullo Jason R |
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| Institution: | Department of Chemistry Research and Discovery, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, USA. erin.dimauro@amgen.com |
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| Abstract: | The rapid and efficient synthesis of various disubstituted 5,6-fused heterocycles using a microwave-assisted one-pot cyclization-Suzuki coupling approach is described. This work highlights the tolerance of the boronic ester functional group to a variety of reaction conditions and the utility of functionalized boronates as penultimate intermediates in the synthesis of diverse compound libraries. |
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