Palladium-catalyzed diastereoselective coupling of propargylic oxiranes with terminal alkynes |
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Authors: | Yoshida Masahiro Hayashi Maiko Shishido Kozo |
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Institution: | Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78-1 Sho-machi, Tokushima 770-8505, Japan. yoshida@ph.tokushima-u.ac.jp |
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Abstract: | reaction: see text] A diastereoselective coupling of propargylic oxiranes with terminal alkynes has been developed with use of a palladium catalyst. The stereochemistries of the resulting 4-alkynyl-substituted 2,3-allenols have been altered depending on the palladium catalyst. An optically active anti-substituted allene was synthesized from the reaction of an enantiomerically enriched propargylic oxirane without loss of chirality. |
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