Multifunctional Core–Shell Upconverting Nanoparticles for Imaging and Photodynamic Therapy of Liver Cancer Cells |
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| Authors: | Zengxia Zhao Yuning Han Chenghong Lin Dong Hu Fang Wang Prof Xiaolan Chen Prof Zhong Chen Prof Nanfeng Zheng |
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| Institution: | 1. State Key Laboratory for Physical Chemistry of Solid, Surfaces and the Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005 (P.R. China), Fax: (+86)?592‐2183047;2. Departments of Electronic Science and Communication Engineering, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, 361005 (P.R. China) |
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| Abstract: | Lanthanide‐doped upconversion nanoparticles (UCNPs) have attracted considerable attention for their application in biomedicine. Here, silica‐coated NaGdF4:Yb,Er/NaGdF4 nanoparticles with a tetrasubstituted carboxy aluminum phthalocyanine (AlC4Pc) photosensitizer covalently incorporated inside the silica shells were prepared and applied in the photodynamic therapy (PDT) and magnetic resonance imaging (MRI) of cancer cells. These UCNP@SiO2(AlC4Pc) nanoparticles were uniform in size, stable against photosensitizer leaching, and highly efficient in photogenerating cytotoxic singlet oxygen under near‐infrared (NIR) light. In vitro studies indicated that these nanoparticles could effectively kill cancer cells upon NIR irradiation. Moreover, the nanoparticles also demonstrated good MR contrast, both in aqueous solution and inside cells. This is the first time that NaGdF4:Yb,Er/NaGdF4 upconversion‐nanocrystal‐based multifunctional nanomaterials have been synthesized and applied in PDT. Our results show that these multifunctional nanoparticles are very promising for applications in versatile imaging diagnosis and as a therapy tool in biomedical engineering. |
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| Keywords: | cancer lanthanides magnetic resonance imaging nanoparticles photodynamic therapy |
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