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An Efficient Approach for the Construction of Benzazepine and Benzoxepine Derivatives |
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| Authors: | Shaoyu Li Dr Shaowu Zou Prof?Dr Jie Wu |
| Institution: | 1. Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433 (China), Fax: (+86) 21 6564 1740;2. Department of Hepatobiliary and Pancreatic Surgery, 10th People's Hospital, Tongji University, 301 Yangchang Middle Road, Shanghai 200072 (China);3. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032 (China) |
| Abstract: | A novel and facile synthetic protocol for the construction of benzazepine and benzoxepine derivatives through a copper(I)‐catalyzed reaction of 2‐(2‐ethynylphenyl)‐1‐tosylaziridine or 2‐(2‐ethynylphenyl)oxirane with sulfonyl azides is disclosed. A ketenimine is the key intermediate during the reaction process. |
| Keywords: | benzazepine benzoxepine copper cyclization homogeneous catalysis |