1‐Bromo‐2‐(cyclopropylidenemethyl)benzene: A Useful Building Block in the Palladium‐Catalyzed Reaction of 2‐Alkynylbenzenamine |
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| Authors: | Shaoyu Li Yong Luo Dr Xiaocong Wang Prof Minjie Guo Prof Jie Wu |
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| Institution: | 1. Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433 (China), Fax: (+86)?216‐564‐1740;2. College of Science, Tianjin University of Science and Technology, Tianjin 300222 (China);3. Key Laboratory of Synthetic Organic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032 (China) |
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| Abstract: | A novel palladium‐catalyzed domino reaction of 1‐bromo‐2‐(cyclopropylidenemethyl)benzene and 2‐alkynylbenzenamine is reported, which generates 2‐(naphthalen‐2‐yl)benzenamines and 5H‐indeno1,2‐c]quinolines via 6‐endo and 5‐exo cyclization, respectively. The regioselectivity for the final outcome can be affected by phosphine and N‐heterocyclic carbene ligands. |
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| Keywords: | cyclization domino reactions homogeneous catalysis palladium synthetic methods |
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