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Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α |
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| Authors: | Dennis L Buckley Dr Jeffrey L Gustafson Dr Inge Van Molle Dr Anke G Roth Dr Hyun Seop Tae Dr Peter C Gareiss Prof William L Jorgensen Dr Alessio Ciulli Prof Craig M Crews |
| Institution: | 1. Departments of Chemistry, Molecular, Cellular & Developmental Biology and Pharmacology and Center for Molecular Discovery, Yale University, New Haven, CT 06511 (USA);2. Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK) |
| Abstract: | |
| Keywords: | drug design E3 ubiquitin ligases protein crystallography protein– protein interactions structure‐based design |