Recent Developments on the Trifluoromethylation of (Hetero)Arenes |
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| Authors: | Dr. Xiao‐Feng Wu Dr. Helfried Neumann Prof. Dr. Matthias Beller |
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| Affiliation: | 1. Department of Chemistry, Zhejiang Sci‐Tech University, Xiasha Campus, Hangzhou, Zhejiang Province, 310018 (People's Republic of China);2. Leibniz‐Institut für Katalyse e.V. Albert‐Einstein‐Strasse 29a, 18059 Rostock (Germany), Fax: (+49)?381‐1281‐5000 |
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| Abstract: | Aryl‐CF3 as an extremely important family of fluorinated organic compounds holds wide applications in pharmaceuticals, agrochemicals, and advanced materials. Traditionally, such trifluoromethylated compounds have been synthesized from the corresponding aryl trichlorides via Cl exchange reactions (Scheme 1 ). This Focus review gives an overview over the recent development of trifluoromethylation of (hetero)arenes. |
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| Keywords: | arenes copper homogeneous catalysis palladium trifluoromethylation |
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