A green and practical method for the synthesis of novel pyrano[2,3-c]pyrazoles and bis-pyrano[2,3-c]pyrazoles using sulfonic acid-functionalized ionic liquid |
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Authors: | Pegah Farokhian Manouchehr Mamaghani Nosrat Ollah Mahmoodi Khalil Tabatabaeian |
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Affiliation: | 1.Department of Chemistry,University of Guilan,Rasht,Iran;2.Department of Chemistry, Faculty of Sciences,University of Guilan,Rasht,Iran |
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Abstract: | An efficient and practical protocol was developed for the synthesis of novel pyrano[2,3-c]pyrazoles and bis-pyrano[2,3-c]pyrazoles by one-pot four-component reaction of arylaldehyde, ethyl acetoacetate, hydrazine hydrate and dimethyl malonate using SO3H-functionalized ionic liquid [DMBSI]HSO4 as a potential green catalyst under solvent-free condition. The method presented is mild, environmentally friendly, inexpensive and functionality tolerant and produces the desired pyranopyrazoles in short reaction times (17–24 min) and excellent yields (85–95%). In addition, the catalyst can be reused at least ten times without almost any change in its catalytic activity. |
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