Synthesis and Insecticidal Activities of Novel Phthalic Acid Diamides |
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| Authors: | Tao Yan Yuxin Li Yongqiang Li Duoyi Wang Wei Chen Zhuo Liu Zhengming Li |
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| Institution: | State Key Laboratory of Elemento‐Organic Chemistry, Institute of Elemento‐Organic Chemistry, Nankai University, Tianjin 300071, China |
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| Abstract: | In order to discover novel insecticides with the new action mode on ryanodine receptor (RyR), a series of novel phthalic acid diamide derivatives were designed and synthesized. All compounds were characterized by 1H NMR spectra and HRMS. The preliminary results of biological activity assessment indicated that some title compounds exhibited excellent insecticidal activities against Mythimna separata, Spodoptera exigua, and Plutella xylostella. The title compound 3‐nitro‐N‐cyclopropyl‐N′‐2‐methyl‐4‐(perfluoropropan‐2‐yl)phenyl]phthalamide ( 4a ) was more efficient against diamondback moths than the control (chlorantraniliprole). The effects of some title compounds on intracellular calcium of neurons from the Spodoptera exigua proved that the title compounds were RyR activators. |
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| Keywords: | phthalic acid diamides insecticidal activity ryanodine receptor activators |
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