Asymmetric Brønsted Acid‐Catalyzed Nazarov Cyclization of Acyclic α‐Alkoxy Dienones |
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| Authors: | Dipl‐Chem Sadiya Raja Dr Winai Ieawsuwan Dr Vadim Korotkov Prof Magnus Rueping |
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| Institution: | Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany), Fax: (+49)?241‐8092665 |
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| Abstract: | A Brønsted acid‐catalyzed asymmetric Nazarov cyclization of acyclic α‐alkoxy dienones has been developed. The reaction offers access to chiral cyclopentenones in a highly enantioselective manner. The reaction is complementary to our previously reported Brønsted acid‐catalyzed electrocyclization reactions, which provided differently substituted optically active cyclopentenones with a fused tetrahydropyrane ring in good yields and with excellent enantioselectivities. |
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| Keywords: | asymmetric synthesis Brø nsted acids electrocyclizations Nazarov reaction organocatalysis |
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