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Solid‐Phase Organic Synthesis of Aryl Vinyl Ethers Using Sulfone‐Linking Strategy |
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| Authors: | Lamei Yu Ni Tang Shouri Sheng Rubing Chen Xiaoling Liu Mingzhong Cai |
| Institution: | College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, China |
| Abstract: | A novel facile solid‐phase organic synthesis of aryl vinyl ethers by reaction of polystyrene‐supported 2‐phenylsulfonylethanol with phenols under Mitsunobu conditions and subsequent elimination reaction with DBU has been developed. The advantages of this method include straightforward operation, good yield and high purity of the products. Alternatively, a typical example of Suzuki coupling reaction on‐resin was further applied to prepare 4‐phenylphenyl vinyl ether for extending this method. |
| Keywords: | solid‐phase organic synthesis aryl vinyl ether polystyrene‐supported 2‐phenylsulfonylethanol sulfone‐linking Suzuki coupling reaction |