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2′‐Fluoro RNA Shows Increased Watson–Crick H‐Bonding Strength and Stacking Relative to RNA: Evidence from NMR and Thermodynamic Data |
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| Authors: | Dr Amritraj Patra Michael Paolillo Dr Klaus Charisse Dr Muthiah Manoharan Prof Eriks Rozners Prof Martin Egli |
| Institution: | 1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232‐0146 (USA) http://structbio.vanderbilt.edu/～eglim/;2. Department of Chemistry, State University of New York at Binghamton, Binghamton, NY 13902 (USA);3. Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142 (USA) |
| Abstract: | |
| Keywords: | 2′ ‐F RNA hydrogen bonding NMR spectroscopy RNA thermodynamics |