One-pot,three-component synthesis and in vitro antibacterial evaluation of novel 3-amino-N-benzyl-1-aryl-1H-benzo[f]chromene-2-carboxamide derivatives

A series of novel 3-amino-N-benzyl-1-aryl-1H-benzo[f]chromene-2-carboxamides have been synthesized by the reaction of N-benzyl-2-cyanoacetamide with 2-naphthol and aromatic aldehydes in the presence of piperidine as a base. The chemical structures of all the compounds were confirmed by spectroscopic methods as well as elemental analysis. In addition, the antibacterial activities of some target compounds against Gram-negative and Gram-positive bacteria in vitro were determined. Among these compounds, 4b, 4c, 4h and 4i exhibited antibacterial effects. The advantages of the present work reaction are clean reaction, metal-free transition, environmentally friendly approach to prepare different benzo[f]chromene-2-carboxamide derivatives, good yields, low cost, readily available starting materials and in addition does not need cumbersome procedure.