A Novel Method for Biomimetic Synthesis of Mannich Bases |
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| Authors: | Yuan Guo Jing An Zhenhuan Lu Mengjiao Peng |
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| Institution: | Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi 710069, China |
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| Abstract: | Since the early studies of Mannich, Mannich reaction has become an important tool for the synthesis of new compounds. Mannich bases can be either directly employed or used as intermediates. In this work, the one‐carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. 1,3‐Dimethylimidazolidine as a new tetrahydrofolate coenzyme model at formaldehyde oxidation level was used to react with ketone having active hydrogen atoms and amine to give the corresponding Mannich base in good yield by a covert Mannich reaction. A novel method for biomimetic synthesis of various Mannich bases is provided. |
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| Keywords: | 1 3‐dimethylimidazolidine tetrahydrofolate coenzyme model Mannich reaction biomimetic synthesis |
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