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Simultaneous Determination of Caffeine and Acetylsalicylic Acid in Pharmaceutical Formulations Using a Boron‐Doped Diamond Film Electrode by Differential Pulse Voltammetry |
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| Authors: | Eric Oliveira Faria Antônio Carlos Viera Lopes?Junior Dênio Emanuel Pires Souto Fernando Roberto Figueiredo Leite Flávio Santos Damos Rita de?Cássia?Silva?Luz Alexandre Soares dos?Santos Diego Leoni Franco Wallans Torres Pio dos?Santos |
| Institution: | 1. Departamento de Farmácia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 39100‐000 Diamantina – MG, Brasil;2. Departamento de Química, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 39100‐000 Diamantina – MG, Brasil;3. Departamento de Ciências Básicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 39100‐000 Diamantina – MG, Brasil;4. Instituto de Química, Universidade Federal de Uberlandia, 38700‐128 Patos de Minas – MG, Brasil |
| Abstract: | This work presents a simple, fast and low‐cost method for simultaneous determination of acetylsalicylic acid (ASA), without alkaline hydrolysis and caffeine (CF) in pharmaceutical formulations using a boron‐doped diamond as the working electrode through differential pulse voltammetry. A good repeatability was reached for 20 measurements, with a low relative standard deviation of less than 1.0 %. The calibration curves presented a great linear correlation coefficient for both drugs (R=0.999) with a limit of detection of 1.6×10?7 mol L?1 for CF and 2.3×10?7 mol L?1 for ASA. The system was validated in comparison with the official method. |
| Keywords: | Acetylsalicylic acid Caffeine Boron‐doped diamond electrode Voltammetry Analytical methods |