Induction of Apoptosis by Ribosome Inactivating Proteins |
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Authors: | Mrinal Kumar Das Radhey Shyam Sharma Vandana Mishra |
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Institution: | (1) Department of Environmental Studies, Laboratory of Bioresources & Environmental Biotechnology, University of Delhi, Delhi, -110 007, India; |
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Abstract: | Apoptotic cell death is a fundamental process in the development and physiological homeostasis of multicellular organisms.
It is associated with control of cell numbers in tissues and organs during development, with cell turnover, and with response
to infection. Molecules that trigger this process in continuously proliferating cancer cells can be used as chemotherapeutic
agents. Ribosome inactivating proteins (RIPs) that inhibit translation in a cell by depurinating (N-glycosidase activity) the 28S rRNA are known to serve as apoptosis inducers. However, the role of depurination activity of
the RIPs in apoptosis induction is still controversial. Presently, there are three different hypotheses which propose that
depurination is: (1) essential, (2) essential but not the sole factor, or (3) not essential for apoptosis induction. This
article reviews various experimental outcomes on the importance of N-glycosidase activity of RIPs in the induction of apoptosis. |
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