A role for cryptochromes in sleep regulation |
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| Authors: | Jonathan P Wisor Bruce F O'Hara Akira Terao Chris P Selby Thomas S Kilduff Aziz Sancar Dale M Edgar Paul Franken |
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| Institution: | (1) Dept. of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA;(2) Dept. of Biological Sciences, Stanford University, Stanford, CA, USA;(3) Molecular Neurobiology Laboratory, SRI International, Menlo Park, CA, USA;(4) Dept. of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, NC, USA |
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| Abstract: | Background The cryptochrome 1 and 2 genes (cry1 and cry2) are necessary for the generation of circadian rhythms, as mice lacking both of these genes (cry1,2 -/-) lack circadian rhythms. We studied sleep in cry1,2 -/- mice under baseline conditions as well as under conditions of constant darkness and enforced wakefulness to determine whether cryptochromes influence sleep regulatory processes. |
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