Alleviation of the chlorpromazine-induced muscular tissue damage by β-cyclodextrin complexation |
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| Authors: | Tetsumi Irie Masaki Otagiri Kaneto Uekama Yoshiro Okano Takeshi Miyata |
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| Institution: | (1) Faculty of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, 862 Kumamoto, Japan |
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| Abstract: | From the gross and histological examinations,  -cyclodextrin (-CyD) was found to reduce the muscular tissue damage produced by chlorpromazine hydrochloride (CPZ) onM. vastus lateralis in rabbits. The protective effect of -CyD may be attributable to the decrease in affinity of CPZ to the tissue membrane through inclusion complexation. There was no appreciable difference in the pharmacokinetic and pharmacodynamic behaviors between CPZ and its -CyD complex in rabbits. These results suggest that -CyD is useful to reduce the local tissue toxicity of CPZ without altering the pharmacological efficacy. |
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