Interactions of Nabumetone with Cyclodextrins in Solution and in the Solid State |
| |
Authors: | Nerea Goyenechea Miguel Sánchez Itziar Vélaz Carmen Martín Cristina Martínez-Ohárriz Arantxa Zornoza |
| |
Institution: | (1) Departamento de Química y Edafología (Sección Química-Física) Facultad de Ciencias, Universidad de Navarra, 31080 Pamplona, Spain |
| |
Abstract: | The interactions of nabumetone (NAB) with -cyclodextrin ( -CD) and -cyclodextrin ( -CD) were studied in aqueous solution by meansof phase-solubility analysis. Solid dispersions of NAB with -cyclodextrin( -CD), -cyclodextrin ( -CD), methyl - (M -CD),hydroxypropyl -cyclodextrin (HP -CD) were prepared by coevaporationand kneading and also by coprecipitation in the case of -CD. X-ray diffractometry, thermal analysis and infrared spectroscopy (FTIR) were used to study the possibility of complexation of the drug with the different cyclodextrins. Solid dispersions of nabumetone with -CD showed a remarkable improvement in the dissolution rate of nabumetone. |
| |
Keywords: | nabumetone solid state solubility diagrams |
本文献已被 SpringerLink 等数据库收录! |