Interactions of Nabumetone with Cyclodextrins in Solution and in the Solid State |
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Authors: | Nerea Goyenechea Miguel Sánchez Itziar Vélaz Carmen Martín Cristina Martínez-Ohárriz Arantxa Zornoza |
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Affiliation: | (1) Departamento de Química y Edafología (Sección Química-Física) Facultad de Ciencias, Universidad de Navarra, 31080 Pamplona, Spain |
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Abstract: | The interactions of nabumetone (NAB) with -cyclodextrin (-CD) and-cyclodextrin (-CD) were studied in aqueous solution by meansof phase-solubility analysis. Solid dispersions of NAB with -cyclodextrin(-CD), -cyclodextrin (-CD), methyl- (M-CD),hydroxypropyl-cyclodextrin (HP-CD) were prepared by coevaporationand kneading and also by coprecipitation in the case of -CD. X-ray diffractometry, thermal analysis and infrared spectroscopy (FTIR) were used to study the possibility of complexation of the drug with the different cyclodextrins. Solid dispersions of nabumetone with -CD showed a remarkable improvement in the dissolution rate of nabumetone. |
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Keywords: | nabumetone solid state solubility diagrams |
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