Seleninate in place of phosphate: irreversible inhibition of protein tyrosine phosphatases |
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| Authors: | Abdo Mohannad Liu Sijiu Zhou Bo Walls Chad D Wu Li Knapp Spencer Zhang Zhong-Yin |
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| Institution: | Department of Chemistry and Chemical Biology, Rutgers The State University of New Jersey, Piscataway, New Jersey 08854, USA. |
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| Abstract: | A homotyrosine based seleninic acid irreversibly inhibits protein tyrosine phosphatases by forming a covalent selenosulfide linkage with the active site cysteine sulfhydryl specifically. The details of the event are revealed by model synthetic studies and by kinetic, mass spectrometric, and crystallographic characterization. |
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