| 3-取代苄氧基-6-取代氨基哒嗪衍生物的合成及其除草活性 |
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| 引用本文： | 胡方中,张敏,朱有全,邹小毛,刘斌,杨华铮. 3-取代苄氧基-6-取代氨基哒嗪衍生物的合成及其除草活性[J]. 有机化学, 2007, 27(12): 1530-1536 |
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| 作者姓名： | 胡方中 张敏 朱有全 邹小毛 刘斌 杨华铮 |
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| 作者单位： | 南开大学元素有机化学研究所,元素有机化学国家重点实验室,天津,300071 |
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| 基金项目： | 国家重点基础研究发展计划(973计划,No.2003CB114400)，国家自然科学青年基金(No.20302004)，教育部博士点基金资助项目. |
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| 摘 要： | 通过3-取代苄氧基-6-氟哒嗪在75～80 ℃与二甲胺的绝对无水乙醇溶液封管反应, 或在回流条件下分别与吗啡啉或哌啶反应, 合成一系列新颖的3-取代苄氧基-6-取代氨基哒嗪类化合物, 它们的结构均经IR, 1H NMR和元素分析确证. 初步的除草活性测定结果表明, 该类化合物具有一定的除草活性, 讨论了它们的结构与除草活性的关系.
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| 关 键 词： | 3-取代苄氧基-6-取代氨基哒嗪 合成 除草活性 构效关系 |
| 收稿时间： | 2007-01-19 |
| 修稿时间： | 2007-06-22 |
Synthesis and Herbicidal Activity of 3-(Substituted benzyloxy)- 6-(substituted amino)pyridazines |
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| HU,Fang-Zhong,ZHANG,Min,ZHU,You-Quan,ZOU,Xiao-Mao,LIU,Bin,YANG,Hua-Zheng. Synthesis and Herbicidal Activity of 3-(Substituted benzyloxy)- 6-(substituted amino)pyridazines[J]. Chinese Journal of Organic Chemistry, 2007, 27(12): 1530-1536 |
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| Authors: | HU Fang-Zhong ZHANG Min ZHU You-Quan ZOU Xiao-Mao LIU Bin YANG Hua-Zheng |
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| Affiliation: | (State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University,Tianjin 300071) |
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| Abstract: | A series of new 3-(substituted benzyloxy)-6-(substituted amino)pyridazines were synthesized through the reaction of 3-(substituted benzyloxy)-6-fluoropyridazines with the solution of dimethylamine in absolute ethanol in a sealed tube in 75～80 ℃ or with morpholine or piperidine under reflux, respectively. The title compounds were identified by IR, 1H NMR spectra and elemental analyses. Preliminary bioassay showed that some of them had certain extent herbicidal activities, and the structure-activity relationship was also discussed. |
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| Keywords: | 3-(substituted benzyloxy)-6-(substituted amino)pyridazine synthesis herbicidal activity structure-activity relationship |
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